ArthriMAXX PREMIUM Soft Chews™ For Dogs

ArthriMAXX PREMIUM Soft Chews™
ArthriMAXX PREMIUM Soft Chews™ For Dogs
$41.88

per 120 ct bottle


What makes ArthriMAXX PREMIUM™ soft chews superior to other soft chews on the market?



  • It is formulated and manufactured in an FDA, cGMP and pharmaceutically licensed facility under strict quality control.

  • It's easy for you to use; just give as a treat after meals or before “bedtime”.

  • It is cold-processed for stability and longer shelf life, which ensures both higher absorption and easier assimilation for full potency.

  • The ingredients in ArthriMAXX PREMIUM™ are being utilized in our liquid formula by prestigious animal hospitals and veterinary specialists across the country.

  • ArthriMAXX PREMIUM™ contains no starch, salt, wheat, yeast, corn, milk or soy derivatives.

  • ArthriMAXX PREMIUM™ is safe, effective and has no known adverse side effects.

Description

Details

Indications for use

  • Musculoskeletal disorders
  • Hip dysplasia
  • Elbow dysplasia
  • Stifle disorders
  • Osteoarthritis
  • OCD (Osteochondritis Dissecans)
  • Post-op orthopedic surgery
  • Lameness
  • Breed related musculoskeletal disorders
  • Subluxation of the hip
  • Patella luxation
  • Traumatic arthritis (minor sprains)
  • Cystitis

As a preventative in

  • Large breed fast growing puppies
  • Sporting dogs
  • Working dogs
  • Agility dogs
  • Young large breed dogs
  • Dogs over the age of 9 years
  • Breed related musculoskeletal disorders
  • Osteoarthritis
  • Cystitis
  • Cardiomyopathy
  • Lameness
ArthriMAXX PREMIUM™ Active Ingredients
  ArthriMAXX PREMIUM™ for Dogs (per 7.5 gram soft chew) 120-count bottle
Glucosamine HCL 500 mg
MSM (methylsulfonylmethane) 500 mg
New Zealand Perna Mussel 300 mg
Alpha Linolenic Acid (Derived from 400 mg Flaxseed Oil) 200 mg
Turmeric 100 mg
Vitamin C (as Calcium Ascorbate) 75 mg
African Hook Plant 50 mg
Manganese Amino Acid Chelate 10 mg
Eicosapentaenoic Acid (EPA) 9 mg
Docosahexaenoic Acid (DHA) 6 mg
Selenium 10 mcg

Learn more about the ingredients for Dogs

ArthriMAXX™ is a combination of powerful Nutraceuticals, Antioxidants and Anti-inflammatory ingredients, which are especially formulated for dogs with joint ailments. We bring you the best of science and nature together to work synergistically with each other. This ensures that your dog is getting the benefits from every ingredient:

Glucosamine HCL (750mg) helps form all the major cushioning ingredients. You can think of it as padding of the joint fluids and surrounding tissues. Glucosamine increases the chance for positive results in a short period of time for a variety of problems. This includes the breakdown and inflammation of the synovial fluids as well as damage to the tissues, ligaments, muscles, inflamed discs and inflamed joints associated with aging. Glucosamine helps to make the synovial fluid thick and elastic. (Refer to diagrams).

Chondroitin sulfate (500mg) is one of the most vital of compounds in connective tissue. It is responsible for building and supporting the ground substance of cartilage. You can think of chondroitin as a bunch of magnets attracting fluid and sweeping nutrients into the cartilage. Chondroitin helps to block destructive enzymes that break down the cartilage in the joint. Chondroitin is also one of the nutraceuticals necessary for the synthesis of glycosaminoglycans.

MSM (methylsulfonylmethane 750mg) is an amazing naturally occurring vital nutrient found in all living organisms. It has many desirable properties and effects for wellness and over all good health. MSM is a major building block of glycosaminoglycans. Glycosaminoglycans are key structural components in cartilage. They also play an important role in the maintenance of joint cartilage. MSM increases blood circulation and is a natural anti-inflammatory. MSM is recognized as the third most important nutrient found in the body of all living mammals. MSM is frequently referred to as "nature's miracle healing nutrient."

Astaxanthin (haematococcus pluvialis 1mg) is in the carotenoid family and is 400 times more powerful than vitamin E. Oxidative damage plays a significant role in the aging process and advancement of degenerative joint disease. Antioxidants can be the key to fighting free radicals. Astaxanthin has been referred to as the "super vitamin E" for distinguishing itself from other antioxidants by it's superior antioxidant potency and bio-availability.

Ester-C (calcium ascorbate 175mg) is the only patented form of vitamin C. It strengthens the immune system, supports joints and connective tissues. Ester-C is essential for the formation and maintenance of collagen, which is vital to bones. Ester-C is non-acidic and gentle on the stomach. Ester-C contains metabolites that have been shown to enhance the delivery of essential vitamin C and may protect against osteoarthritis.

Aloe Vera (300mg) has always been referred to as the "Miracle Plant." Most of us are familiar with its properties for burns. There are extensive amounts of evidence showing its healing properties for combating inflammation and swelling. Its anesthetic action eases pain and enhances blood flow. It contains chemicals that penetrate deep inside the cell membranes. This enables it to deliver beneficial compounds deep into tissue where it can do the most good. Aloe Vera is also known by millions as "God's gift to mankind."

Manganese (10mg) is essential for normal bone structure. It can also help neutralize free radicals and is needed for normal nerve function. Manganese is also indicated in stimulating growth of connective tissue and is also thought to be of importance in the growth and development of the formation of mucopolysaccharides, which are needed for healthy joint membranes.

Clinical References on the ingredients in ArthriMAXX PREMIUM Soft Chews™

Bendich A. Carotenoids and the immune response. J. Nutrition 1989: 119: 112-115

Chew BP, Park JS.Carotenoid action on the immune response.J Nutr. 2004 Jan;134(1):257S-261S. Review.
PMID: 14704330

Das A Jr. Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50.

Deal CL, Moskowitz RW: Nutraceuticals as therapeutic agents in osteoarthritis. Rheum Dis Clin North AM 25(2):379-395, 1999

Denham AC, Newton WP. Are glucosamine and chondroitin effective in treating osteoarthritis? J Fam Pract. 2000 Jun;49(6):571-2.

Geir Erik Berge. Polyascorbate(Ester-C®), an interesting alternative by problems in the support and movement apparatus in dogs. Norwegian Veterinary Journal, Vol:102, August/September 1990.

Goldsmith T. et al Vision Research. 1984. 24 (11) 1661-1671.

Gradelet S, Le Bon AM, Berges R, Suschetet M, et al. Dietary carotenoids inhibit aflatoxin B1- induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism. Carcinogenesis. 1998 Mar:19(3):403-11.

Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition.Trends Biotechnol. 2003 May;21(5):210-6. Review.PMID: 12727382

Hix LM, Lockwood SF, Bertram JS.Bioactive carotenoids: potent antioxidants and regulators of gene expression. Redox Rep. 2004;9(4):181-91. Review.

Hussein G, Goto H, Oda S, Iguchi T, Sankawa U, Matsumoto K, Watanabe H. Antihypertensive potential and mechanism of action of astaxanthin: II. Vascular reactivity and hemorheology in spontaneously hypertensive rats.
Biol Pharm Bull. 2005 Jun;28(6):967-71.

Johnson KA, Hulse DA, Hart RC, et al Efffects of orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin 3B3 and 7D4 epitope in a canine cruciate ligament transaction model of osteoarthritis. Osteoarthritis Cartilage.2001 Jan;9(1):14-21.

Jyonouchi H, Sun S, Iijima K, Gross MD. Antitumor activity of astaxanthin and its mode of action. Nutr Cancer. 2000;36(1):59-65.

Jyonouchi H, et al. Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T helper cell clones and suboptimal doses of antigen. 1995; 125(10) :2483-249

Lee SJ, Bai SK, Lee KS, et al.Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF kappaB activation. Mol Cells. 2003 Aug 31; 16(1):97-105

Leffler CT, Philippi AF, Leffler SG, et al. Glucosamine,Chondroitin and Manganese ascorbate for degenerative joint diease of the knee or low back: a randomized, double blind, placebo-controlled pilot study. Mil Med.1999;164(2):85-91

Lippiello L, Woodward J, Karpman R et al. In Vivo Chondroprotection and Metabolic Synergy of Glucosamine and Chondroitin Sulfate. Clinical Orthopedics and Related Research, Vol. 381:229-240, December, 2000

Lockwood SF, Gross GJ. Disodium disuccinate astaxanthin (Cardax): antioxidant and anti-inflammatory
cardioprotection. Cardiovasc Drug Rev. 2005 Fall;23(3):199-216.

McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000 Mar 15;283(11):1469-75

McLaughlin R DVM,DVSc DACVS, Roush J, DVM, MS, DACVS. Medical Therapy for patients with osteoarthritis VetMed97(2):135-44 Feb 2002 Symposium 60 Refs.

Miki W.Recent advances in carotenoid studies--metabolisms and bioactivities. J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:469-72.

Miki, W., “Biological Functions and Activities of Animal Carotenoids,” Pure and Applied Chemistry, 1991: 63(1) pp. 141-146

Naguib YM.Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem. 2000 Apr;48(4):1150-4.

Naito Y, Uchiyama K, Aoi W, Hasegawa G, Nakamura N, Yoshida N, Maoka T, Takahashi J, Yoshikawa T. Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors. 2004;20(1):49-59.

Okai Y and K. Higashi-Okai. Possible immunomodulating activities of carotenoids in in vitro cell culture experiments. Int. J Immunopharmacol., 1996. 18: 753-758.
Palozza P, Krinsky NI. Astaxanthin and canthaxanthin are potent antioxidants in a membrane model.
Arch Biochem Biophys. 1992 Sep;297(2):291-5.

Parcell S. Sulfur in human nutrition and application in medicine. American institute for Biosocial and Medical Research(AIBMR), Tacoma, WA

Pavelka K, Gatterova J, Olejarova M, et al Glucosamine sulfate use and delay of progreeion of knee osteoarthritis: a 3- year, randomized, placebo-controlled,double-blind study. Arch Intern Med. 2002 Oct 14;162(18):2113-23.

Reginster JY, Gillot V, Bruyere O, et al. Evidence of nutriceutical effectiveness in the treatment of osteoarthritis. Curr Rheumatol Rep. 2000 Dec;2(6):472-7. Review.

Savoure M, Briand G, Amory-Touz MC et al. Vitamin A status and metabolism of cutaneous polyamines in the hairless mouse after UV irradiation: action of Beta carotene and astaxanthin. Int J. Vitam Nutr Res 1995;65(2) :79-86

Schenck RC: Osteoarthritis treatment and potential structure modification with nutraceuticals. Orthopedic Special Edition Special Report: 1-4, August 1999

Spiller G. Studies show BioAstin relieves pain and improves performance in patients with rheumatoid arthritis and carpal tunnel syndrome in double blind, placebo controlled studies. Health research studies center in Los Altos, CA.

Tanaka T, Makita H, Ohnishi M, et al. Chemoprevention Of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin. First Dept of Pathology, Gifu University School of Medicine, Japan. Cancer Res. 1995 Sep 15;55(18):4059-64.

Tanaka T, Kawamori T, Ohnishi M, et al.Suppression of azoxymethane-induced rat colon carcinogenesis dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase.
First Dept of Pathology, Gifu University School of Medicine, Japan. Carcinogenesis. 1995 Dec;16(12):2957-63.

Vasquez B. et al. 1996. Anti-inflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol Vol. 55. 69-75

Yoshizawa T, Watanabe S, Hirose M, et al. Dimethylsulfoxide maintains intercellular communication by preserving the gap junctional protein connexin32 in primary cultured hepatocyte doullets from rats. Dept of Gastroenterology,
Juntendo University, School of Med, Tokyo, Japan.

Zerkak D. Dougados M. The use if glucosamine therapy in osteoarthritis. Curr Rheumatol Rep.2004 Feb;6(1):41-5. Review.

Zhang, I. And Tizard. 1996. Activation of mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology 35(2): 119-28

 

References can be also found on
WWW.PUBMED.GOV

For pets weighing 10 lbs. and under, give 1.0 ml daily. For every additional 5lbs. of body weight, add .5 ml daily to their dosage.
ArthriMAXX PREMIUM™ for Dogs Daily Dosage Guideline
5 to 15 lbs 16-25 lbs 26-45 lbs 46-95 lbs 96-130 lbs Over 131 lbs
1/2 chew 1 chew 2 chew 3 chew 4 chew 5 chew

Guarantee: ArthriMAXX™ is a full circle powerful joint formula. Every human grade ingredient in ArthriMAXX™ has and is being used in major clinical studies across the globe. Our patent pending formula makes ArthriMAXX™ unique. Our products and ingredients are researched, developed and manufactured in the USA.
We also stand behind our 100% palatability guarantee.